Journal: Frontiers in Immunology
Article Title: Development of a diagnostic model for MASLD and identification of daidzein as the potential drug using bioinformatics analysis and experiments
doi: 10.3389/fimmu.2025.1698740
Figure Lengend Snippet: Daidzein alleviates MASLD through the ENO3/PPAR signaling pathway. (A) Daidzein reduced the protein expression of ENO3 in primary hepatocytes. (B) GSEA analysis shows the top 10 pathways with high ENO3 expression. (C) Daidzein affects the expression of 3 proteins, PPARα, PPARγ, and PPARD, in primary hepatocytes. (D) Daidzein affects the protein expression of downstream proteins (SCD1,FASN, CD36 and CPT1A) in the PPAR pathway. (E, F) Perform protein quantification analysis of ENO3, PPAR, PPARγ PPARD, CPT-1A, CD36, FASN and SCD1. The experiment was repeated three times. * P < 0.05, ** P < 0.01, *** P < 0.001.
Article Snippet: ENO3 , Rabbit , Proteintech; 55234-1-AP.
Techniques: Expressing